At Stanford University, the CIMAC utilizes innovative technology to perform highly comprehensive assays of immune phenotype and function for immunotherapy clinical trials within the CITN, Ped-CITN, COG and PBTC. These include CyTOF mass cytometry, Multiplexed Ion Beam Imaging (MIBI), ATACseq, Single-cell TCRseq and targeted gene expression, high-dimensional flow cytometry and highly multiplexed Luminex. Furthermore, this group has extensive sample tracking and pathology support from the Human Immune Monitoring Center as well as the CTRU (Biobank OS online database) and the Stanford Tissue/ Histopathology core. As a result of the wide range of resources and immune monitoring experience, this CIMAC can develop and apply novel algorithms for analyzing specific questions arising with clinical collaborators as needed.
Holden Maecker, PhD, is a Professor (research) of Microbiology and Immunology at Stanford University. He is Director of Stanford’s Human Immune Monitoring Center as well as Service Centers and Enabling Technologies at the medical school. His expertise is mainly in using systems level immune monitoring assays to understand the correlation between cellular response to pathogens and cancer and protection from clinical disease.
Sean Bendall, PhD is an Assistant Professor (research) of Pathology at Stanford University and an expert on high-content single-cell analysis (CyTOF – Mass Cytometry) and imaging (MIBI – Multiplexed Ion Beam Imaging). His research focuses on using these techniques to investigate how novel regulators enable the mechanistic characterization of human pathophysiology in primary tissues.