The Icahn School of Medicine at Mount Sinai CIMAC brings together immunologists, technologists, clinicians, computational biologists, data specialists, and biostatisticians with expertise in CYTOF mass cytometry phenotyping, Multiplex ImmunohistoChemical Staining on a Single Slide (MICSSS), serology, soluble analytes (Olink), seromics, and microbiome composition.

Using biological assay protocols and computational methods from the Precision Immunology Institute and the Tisch Cancer Institute at the Icahn School of Medicine, the Mount Sinai CIMAC provides exceptional integration of data and automated analyses pipelines.

Principal investigators

Photo of Sacha Gnjatic, PhD

Sacha Gnjatic, PhD

Associate Director, Human Immune Monitoring Center, Mount Sinai

Associate Professor, Hematology and Medical Oncology, and Oncological Sciences, Icahn School of Medicine

Dr. Gnjatic focuses on human immune responses to cancer in an antigen-specific manner to define new targets for the development of cancer immunotherapies and ask how these immunotherapies work and why they may fail. Areas of research include: Characterization of serological and cellular immune responses against tumor antigens such as MAGE-A3 or NY-ESO-1, whether spontaneously occurring or induced by cancer immunotherapy, using state-of-the-art T cell methods and large-scale seromic profiling; mechanisms of antigen presentation to T cells to evaluate viral, bacterial, and parasitic vectors and cross-presentation of antigen to HLA; and impact of immunoregulation on tumor antigen-specific responses, from co-inhibitory molecules expressed on T cells at the tumor site to the effect of regulatory T cells and immune checkpoint blockade on anti-tumor effectors, with a recent emphasis on the role of immunosuppressive mechanisms in the tumor microenvironment.