The CIDC, housed at Dana-Farber Cancer Institute, serves the bioinformatics needs of the CIMAC-CIDC Network, including optimization of data collection methodologies suitable for immune-related biomarkers and data integration.
With the goal of developing a biomarker database for secondary use by the broader immuno-oncology community, CIDC is responsible for:
- Creating data standards for all CIMAC assays
- Creating and maintaining a centralized data repository and coordinated activities for CIMAC data submission to the CIDC
- Developing and maintaining uniform bioinformatics pipelines for standardization of CIMAC data
- Developing a shared infrastructure for executing integrative and correlative analysis on all CIMAC data
- Developing data APIs and role-based access
- Developing data visualization tools, enabling CIMAC investigators and external researchers to conduct their own analyses
- Coordinating CIMAC-CIDC Network logistic and scientific activities for biomarker discovery and validation
Principal investigators
Franziska Michor, PhD
Professor of Computational Biology, Department of Data Science, Dana-Farber Cancer Institute
Professor of Computational Biology, Department of Biostatistics, Harvard T.H. Chan School of Public Health
Professor of Stem Cell and Regenerative Biology, Department of Stem Cell and Regenerative Biology, Harvard University
Dr. Michor is a Professor of Computational Biology in the Department of Data Sciences at the Dana-Farber Cancer Institute, in the Department of Biostatistics at the Harvard T.H. Chan School of Public Health, and in the Department of Stem Cell and Regenerative Biology at Harvard University. She has been the recipient of the Theodosius Dobzhansky Prize of the Society for the Study of Evolution, the Alice Hamilton Award, the Vilcek Prize for Creative Promise in Biomedical Science, the 36th Annual AACR Award for Outstanding Achievement in Cancer Research, and others. Dr. Michor's laboratory investigates the evolutionary dynamics of cancer initiation, progression, response to therapy, and emergence of resistance.
Ethan Cerami, PhD
Director, Knowledge Systems Group and Principal Scientist, Department of Data Science, Dana-Farber Cancer Institute
Dr. Cerami's group focuses on building open-source bioinformatics platforms to enable cancer genomics discovery and precision cancer medicine. While at Memorial Sloan Kettering Cancer Center, he co-founded the cBioPortal for Cancer Genomics, one of the most widely used platforms for cancer genomics analysis and visualization. His group remains active in its continued development. He is also currently the Co-PI of the National Cancer Institute Human Tumor Atlas Network (HTAN) Data Coordinating Center (DCC), and the Co-PI of the DFCI MatchMiner platform for algorithmically matching patients to precision cancer medicine trials.