CIMAC-CIDC Network Assays

Each CIMAC provides a wide range of state-of-the-art analyses for genomic, phenotypic and functional assays using analytically-validated platforms and harmonized protocols to allow comparison of datasets across all CIMAC sites. The following table shows the availability of each assay in the network. More than one CIMAC laboratory may collaborate on a single trial to provide multiple specialized assays. For more information about a specific assay used by the CIMAC laboratories, click on the title of the assay (in purple). Currently, only tier-1 assays have harmonized SOPs available. New assays continue to be added to the CIMAC repertoire, and this page will be updated with additional information as it becomes available. Please contact us if you have any questions.

Tier 1 Assays: Broadly recommended for most trials
Tier 2 Assays: Other assays, usage depends on trials

Tissue ImagingAssay TierDana-FarberMD AndersonMt SinaiStanford
Multiplex Immunohistochemistry and Immunofluorescence1
Conventional Immunohistochemistry1
Multiplexed Ion-Beam Imaging (MIBI)2
Cell ProfilingAssay TierDana-FarberMD AndersonMt SinaiStanford
Mass Cytometry (CyTOF)1
High-dimensional Flow Cytometry2
SequencingAssay TierDana-FarberMD AndersonMt SinaiStanford
RNA Sequencing1
Exome Sequencing1
TCR/BCR Clonality2
Single-cell TCRseq2
HLA-Seq: Epitope Prediction2
Neoantigen Prediction2
Cell-free DNA (circulating tumor DNA) 2
Epigenomics (ATAC-Seq)2
HTG-EdgeSeq (gene expression)2
Microbiome (16S Deep Sequencing) 2
Single-cell Transcriptome2
Cytokines/Serum AnalytesAssay TierDana-FarberMD AndersonMt SinaiStanford
O-link Serum Cytokine Analysis1
Seromics-ELISA/Grand Serology2
MesoScale Discovery2