Several working groups support the CIMAC-CIDC Network.

The Biobank Working Group develops a system for specimen tracking, accessioning, and management, as well as develops SOPs for sample collection across trials for specific assay platforms.
Working group leads: David Patton and Radim Moravec

The Clinical Trials Coordination Working Group reviews opportunities for correlative biomarker study collaborations in prospective, ongoing, and closed clinical trials. This panel of clinicians, scientists, and project managers works with clinical trial teams to develop and approve detailed plans for clinical specimen collection and CIMAC-CIDC Network biomarker analysis. This working group also serves as an immunotherapy think tank, curating the network’s portfolio of trial collaborations to reflect promising patient populations and key questions in the field.
Working group leads: Gheath Al-Atrash, Stephen Hodi, Helen Chen

The Assays/Platforms Working Group develops quality control (QC) parameters for clinical specimens to be analyzed, as well as process and workflow for cross-network standardization and analytical validation of assays. This group selects the assays, develops the criteria for their prioritization and approval, and assigns assays to each CIMAC based on identified resources.
Working group leads: Holden Maecker and Magda Thurin

The Genomics and TCRseq Working Group determines approaches for whole exome sequencing (WES), RNAseq, ctDNA, and TCRseq for the CIMAC-CIDC Network, including harmonization considerations, platforms, reference materials, informatics pipelines, and other considerations.
Working group leads: Catherine Wu, Shirley Liu, Kenneth Livak

The Immunohistochemistry (IHC) Working Group determines approaches for singleplex IHC, multiplex IHC/multiplex immunofluorescence (mIHC/mIF), and MIBI for the CIMAC-CIDC Network, including harmonization of approaches across different platforms, reference materials, informatics, and assay validation.
Working group lead: Michael Tetzlaff

The CyTOF Working Group determines approaches for CyTOF for the CIMAC-CIDC Network, including harmonization of protocols, markers to include in panels, reference materials, informatics pipelines, and other considerations.
Working group leads: Holden Maecker, Addeb Rahman, Bita Sahaf, Mina Pichavant

The Bioinformatics Working Group is responsible for the standardization of data collection, processing and quality control methods, and data interpretation for use across the CIMAC-CIDC Network. They also provide centralized biostatistics, bioinformatics, and computational biology expertise for data analysis and interpretation, and evaluate the association between assay results and therapeutic response.
Working group leads: Shirley Liu and Daoud Meerzaman

The Database/Software Working Group addresses data collection, develops common data standards, focuses on the integration of data across different trials, and establishes the data repository for the CIMAC-CIDC Network.
Working group leads: Ethan Cerami and David Patton